Fluid coupling devices can be configured for use in fluid systems for purposes of providing a single-use, aseptic disconnection functionality that can substantially limit fluid spillage when being disconnected. In some embodiments, the coupling portions cannot be functionally reconnected to each other after being disconnected from each other. The coupling portions can be identical to each other in some embodiments. A retainer component of the fluid coupling devices can be removably engaged with the coupling portions while the coupling portions are abutted against each other in an operative arrangement.