- Patent Title: Diagnostic kits and methods configured to rapidly and non-invasively determine physiologic levels of galactose-deficient IgA1 (Gd-IgA1) in the subject of IgA nephropathy
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Application No.: US17084125Application Date: 2020-10-29
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Publication No.: US12000841B2Publication Date: 2024-06-04
- Inventor: Ann Chen , Shuk-Man Ka , Shih-Hsiung Wu
- Applicant: National Defense Medical Center , Academia Sinica
- Applicant Address: TW Taipei
- Assignee: NATIONAL DEFENSE MEDICAL CENTER & ACADEMIA SINICA
- Current Assignee: NATIONAL DEFENSE MEDICAL CENTER & ACADEMIA SINICA
- Current Assignee Address: TW Taipei
- Agency: Muncy, Geissler, Olds & Lowe, P.C
- Main IPC: G01N33/68
- IPC: G01N33/68 ; C07K14/705
Abstract:
The present invention provides a lectin from Crenomytilus grayanus or Mytilus trossulus as diagnostic reagents for IgA nephropathy. The present invention also provides a diagnostic kit for detecting Galactose-deficient IgA1 (Gd-IgA1), comprising RussiaSea-001 (also called as CGL) isolated from Crenomytilus grayanus or RussiaSea-002 (also called as MTL) isolated from Mytilus trossulus. The present invention further provides a method for detecting Gd-IgA1 using RussiaSea-001 or RussiaSea-002.
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