A processing graph of an application with a sequence of processing nodes is obtained which processes an input and generates an intermediate representation a further intermediate representation, and an output representation of the input at stages in the sequence of processing nodes. Graph metadata is generated that specifies a non-overlapping target tiling configuration for the output representation, an overlapping tiling configuration for the input, an overlapping tiling configuration for the intermediate representation, and a third tiling configuration for the further intermediate representation. The processing graph is modified based on the graph metadata to conform to the parameters specified by the graph metadata. A set of computer instructions is then created to execute the modified processing graph on a target processing system.