Disclosed are a method and device in wireless communication. As one embodiment, a UE receives a first signalling, and subsequently receives a first wireless signal on a target time-frequency resource, wherein the first signalling is used for determining at least the former of (a sub-carrier interval corresponding to the first wireless signal, and the target time-frequency resource), and the first signalling is a physical layer signalling. The present invention can dynamically configure a plurality of sub-carrier intervals on the same frequency band, thereby ensuring that different bandwidth requirements corresponding to different applications are satisfied on the same bandwidth. In addition, the present invention prevents a UE from determining a sub-carrier interval by blind detection, thereby reducing the complexity of the UE.