Invention Grant
- Patent Title: Epstein-barr virus vaccines
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Application No.: US16922322Application Date: 2020-07-07
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Publication No.: US12005115B2Publication Date: 2024-06-11
- Inventor: Masaru Kanekiyo , Gary J. Nabel , Jeffrey Cohen , Wei Bu
- Applicant: The USA, as represented by the Secretary, Dept. of Health and Human Services
- Applicant Address: US MD Bethesda
- Assignee: The United States of America as Represented By The Secretary of the Department of Health and Human Services
- Current Assignee: The United States of America as Represented By The Secretary of the Department of Health and Human Services
- Current Assignee Address: US MD Rockville
- Agency: Sughrue Mion, PLLC
- The original application number of the division: US15028655
- Main IPC: A61K39/245
- IPC: A61K39/245 ; A61K39/12 ; C07K14/00 ; C07K14/005 ; C07K14/195 ; C07K16/08 ; C12N7/00 ; A61K39/00

Abstract:
Vaccines are provided that elicit neutralizing antibodies to Epstein-Barr virus (EBV). Some vaccines comprise nanoparticles that display envelope proteins from EBV on their surface. The nanoparticles comprise fusion proteins comprising a monomeric subunit of a self-assembly protein, such as ferritin, joined to at least a portion of an EBV envelope protein. The fusion proteins self-assemble to form the envelope protein-displaying nanoparticles. Such vaccines can be used to vaccinate an individual against infection by different types of Epstein-Barr viruses as well as Epstein-Barr viruses that are antigenically divergent from the virus from which the EBV envelope protein was obtained. Also provided are fusion proteins and nucleic acid molecules encoding such proteins.
Public/Granted literature
- US20200330587A1 EPSTEIN-BARR VIRUS VACCINES Public/Granted day:2020-10-22
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