Invention Grant
- Patent Title: Mitogen-activated protein kinase inhibitors, methods of making, and methods of use thereof
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Application No.: US17863657Application Date: 2022-07-13
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Publication No.: US12006337B2Publication Date: 2024-06-11
- Inventor: Michael J. Holtzman , Arthur G. Romero , Benjamin J. Gerovac , Zhenfu Han , Shamus P. Keeler , Kangyun Wu , Yong Zhang
- Applicant: Washington University
- Applicant Address: US MO St. Louis
- Assignee: WASHINGTON UNIVERSITY
- Current Assignee: WASHINGTON UNIVERSITY
- Current Assignee Address: US MO St. Louis
- Agency: Stinson LLP
- Main IPC: C07D417/06
- IPC: C07D417/06 ; C07D213/75 ; C07F7/08
Abstract:
Compounds that inhibit mitogen-activated protein kinases (MAPKs) are disclosed. Some inhibitor compounds specifically target a single MAPK such as MAPK13, while others target multiple MAPKs such as MAPK13 and MAPK12. The compounds can be used therapeutically for a variety of diseases, including cancer and respiratory diseases. Methods of synthesis of the compounds are also disclosed.
Public/Granted literature
- US20230192728A1 MITOGEN-ACTIVATED PROTEIN KINASE INHIBITORS, METHODS OF MAKING, AND METHODS OF USE THEREOF Public/Granted day:2023-06-22
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