Invention Grant
- Patent Title: Olaparib oxalic acid cocrystals and their pharmaceutical use
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Application No.: US18245624Application Date: 2021-09-14
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Publication No.: US12012386B2Publication Date: 2024-06-18
- Inventor: Joanne Holland , Alex Eberlin , Christopher Frampton
- Applicant: NUFORMIX TECHNOLOGIES LIMITED
- Applicant Address: GB London
- Assignee: NUFORMIX TECHNOLOGIES LIMITED
- Current Assignee: NUFORMIX TECHNOLOGIES LIMITED
- Current Assignee Address: GB London
- Agency: RAPHAEL BELLUM PLLC
- International Application: PCT/IB2021/000617 2021.09.14
- International Announcement: WO2022/058785A 2022.03.24
- Date entered country: 2023-03-16
- Main IPC: C07D237/32
- IPC: C07D237/32

Abstract:
The invention relates to new olaparib oxalic acid cocrystals. The olaparib oxalic acid cocrystals vary in ratio from 1:1 to 2:3 olaparib:oxalic acid. In particular, the invention relates to a 2:3 olaparib oxalic acid cocrystal, a 1:1 olaparib oxalic acid cocrystal, and a 2:1 olaparib oxalic acid cocrystal. The invention also relates to pharmaceutical compositions containing an olaparib oxalic acid cocrystal of the invention and a pharmaceutically acceptable carrier. The olaparib oxalic acid cocrystals of the invention Got may be useful for the treatment of diseases that benefit from inhibition of poly (ADP-ribose) polymerase (PARP). These include cancer, fibrosis, inflammatory conditions (e.g. asthma, colitis, arthritis), neurological diseases (e.g. neurodegeneration, neurotrauma, stroke), cardiovascular conditions, ophthalmic degenerative diseases, vascular diseases (e.g. diabetic complications, atherosclerosis), and various forms of critical illness (e.g. septic shock, ALI, acute liver failure).
Public/Granted literature
- US20230322686A1 OLAPARIB OXALIC ACID COCRYSTALS AND THEIR PHARMACEUTICAL USE Public/Granted day:2023-10-12
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