A reverse polarity protection circuit of a DC-DC converter includes an inductive component. When the DC-DC converter is connected to a power supply with correct polarity, the inductive component of the converter receives power via a body diode of a protection switch. Once the inductive component begins to charge and discharge under control of a driving switch, the protection switch turns on and allows full power to be provided to the inductive component. When the DC-DC converter is connected with reverse polarity, a clamping switch fed by the power supply turns on and connects a control input of the protection switch to ground, turning off the protection switch. The clamping switch is protected by a switch protection device to lower the voltage difference between a control input of the clamping switch and an input of the clamping switch.