Hydraulic design method, device and equipment for mobile drip irrigation system are provided. Different distances between drip-lines, a depth of a bottom boundary, a flux of infiltration boundary and soil hydraulic parameters are input into a simulation model, and output parameters of the model including a soil water content at each observation point and an amount of deep percolation loss under the different distances at the same irrigation depth are acquired. An optimal distance between drip-lines is obtained according to an installation cost function, the soil water content at each observation point and the amount of deep percolation loss, and lengths of drip-lines matched with the optimal distance are obtained. Structural parameters of the irrigation system and a designed irrigation depth are obtained to determine working parameters. The irrigation system with the optimal distance and the matched lengths of drip-lines is controlled to irrigate crops based on the working parameters.