System and method for measuring diabetes mellitus condition of a subject is disclosed. The disclosed system and method includes thermal sensors for capturing thermal images and/or videos of a body part; and a processing engine to detect a predefined region of the body part in each frame of the captured images and/or videos. The processing engine segments one or more portions from the detected predefined region in each frame of the captured images and/or videos to identify a region of interest comprising major arteries in the segmented portions. Based on the ROI, the engine extracts pixel values, representing biosignals, from each frame of the captured images and/or videos so as to determine one or more parameters associated with the hemodynamic factors and a rate of atherosclerosis of the subject. Further, a risk score for the diabetes mellitus condition based on the determined parameters using computational models is measured.