Invention Grant
- Patent Title: Platinum-acridine compounds and methods of treating cancers
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Application No.: US17235382Application Date: 2021-04-20
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Publication No.: US12023341B2Publication Date: 2024-07-02
- Inventor: Ulrich Bierbach , Shenjie Zhang , Xiyuan Yao , Ikeer Y. Mancera-Ortiz , Noah H. Watkins
- Applicant: Wake Forest University
- Applicant Address: US NC Winston-Salem
- Assignee: Wake Forest University
- Current Assignee: Wake Forest University
- Current Assignee Address: US NC Winston-Salem
- Agency: Fox Rothschild LLP
- Main IPC: C07F15/00
- IPC: C07F15/00 ; A61K31/165 ; A61K31/19 ; A61K31/4406 ; A61K31/444 ; A61K31/455 ; A61K31/496 ; A61K31/519 ; A61K31/5377 ; A61K31/555 ; A61K31/706 ; A61K38/15 ; A61P35/00
Abstract:
Platinum-acridines and analogs thereof as cytotoxic agents for cancer treatment. Also provided methods of using hMATE1 (SLC47A1) as a biomarker to identify tumors that are likely to respond to the agents, and epigenetically sensitizing tumor tissue to anticancer drugs targeting this membrane transporter.
Public/Granted literature
- US20210330679A1 PLATINUM-ACRIDINE COMPOUNDS AND METHODS OF TREATING CANCERS Public/Granted day:2021-10-28
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