Provided is a stem cell filtrate preparation useful for hair regeneration, alleviation of pain caused by a disease of an interosseous joint, such as osteoarthrosis or rheumatoid arthritis, and treatment of the disease, and in addition, restoration of a damaged muscle, and prevention or treatment of decubitus. The stem cell filtrate preparation according to one aspect of the present invention is characterized by including a filtrate of a stem cell from which a cell membrane is removed. The stem cell may be at least one selected from at least one selected from an adipose-tissue-derived mesenchymal stem cell, an epithelial stem cell, a pigmented stem cell, an iPS cell, and an ES cell. Furthermore, the stem cell filtrate preparation includes an adipocyte or an effective component extracted from cellular fat.