Invention Grant
- Patent Title: Amorphous efinaconazole solid dispersion
-
Application No.: US17762272Application Date: 2020-09-25
-
Publication No.: US12023408B2Publication Date: 2024-07-02
- Inventor: Eun Ju Park , Hyun Ji , Ji Eun Lee , Jin Oh Park
- Applicant: DAEBONG LS CO., LTD.
- Applicant Address: KR Incheon
- Assignee: DAEBONG LS CO., LTD.
- Current Assignee: DAEBONG LS CO., LTD.
- Current Assignee Address: KR Incheon
- Agency: NKL LAW
- Agent Jae Youn Kim
- Priority: KR 20190118647 2019.09.26
- International Application: PCT/KR2020/013164 2020.09.25
- International Announcement: WO2021/060950A 2021.04.01
- Date entered country: 2022-03-21
- Main IPC: A61K31/454
- IPC: A61K31/454 ; A61K9/16 ; C07D401/06

Abstract:
A solid dispersion of amorphous efinaconazole and a method for preparing the same are proposed. The solid dispersion includes an amorphous form of efinaconazole and at least one stabilization carrier selected from hydroxypropyl methylcellulose (HPMC), hydroxypropyl cellulose (HPC), ethyl cellulose (EC), hydroxypropyl methylcellulose acetate succinate (HPMC-AS), polyvinylpyrrolidone (PVP), polyacrylic acid (PAA), saccharin, and malonic acid. The solid dispersion undergoes minimal thermodynamic deformation when exposed to ambient temperature and humidity, achieving improved stability, while maintaining the inherent improved stability and bioavailability of amorphous efinaconazole.
Public/Granted literature
- US20220387323A1 AMORPHOUS EFINACONAZOLE SOLID DISPERSION Public/Granted day:2022-12-08
Information query
IPC分类: