The present disclosure provides a wheel speed sensor interface circuit, an operation method thereof, and an electronic control system, the wheel speed sensor interface circuit comprising: a first signal processing unit for receiving a first current signal sensed by a high side of a wheel speed sensor and processing the first current signal to output a first voltage signal; a second signal processing unit for receiving a second current signal sensed by a low side of the wheel speed sensor and processing the second current signal to output a second voltage signal; and a verification unit for comparing the first voltage signal and the second voltage signal with each other and verifying whether the first voltage signal and the second voltage signal are normal. According to the present disclosure, reliability and redundancy for a process of transmitting wheel speed information can be secured.