Invention Grant
![Processes for the preparation of 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)-pyrrolidin-2-yl]imidazo[1,5-a]-pyrazin-1-yl}N-(pyridin-2-yl)-benzamide](/docs/US/2024-07-02/US12024520B2/abs.jpg.600x600.jpg)
- Patent Title: Processes for the preparation of 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)-pyrrolidin-2-yl]imidazo[1,5-a]-pyrazin-1-yl}N-(pyridin-2-yl)-benzamide
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Application No.: US17271750Application Date: 2019-08-28
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Publication No.: US12024520B2Publication Date: 2024-07-02
- Inventor: Paul Allen Bethel , Lai Chun Chan , Katie Grace Cooper , Robert John Cox , Michael David Golden , Shaun Alan Hughes , Lucinda Victoria Jackson , Kirsty Jane Millard , Andrew John Phillips , Alexander James Telford , Jerry Evarts , Michael Joseph Lawler , Remy E. J. N. Litjens , Peter Johannes Servaas Savio Van Eijk , Mathilda Maria Henrica Verstappen , Frank L. M. Vos , Eric Jurriën Zijp , Qiu Junying , Rustam Ferdinand Garrey , David Allen Short , Angang Wang
- Applicant: Acerta Pharma B.V.
- Applicant Address: NL Oss
- Assignee: ACERTA PHARMA B.V.
- Current Assignee: ACERTA PHARMA B.V.
- Current Assignee Address: NL Oss
- International Application: PCT/EP2019/072991 2019.08.28
- International Announcement: WO2020/043787A 2020.03.05
- Date entered country: 2021-02-26
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07B63/00
![Processes for the preparation of 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)-pyrrolidin-2-yl]imidazo[1,5-a]-pyrazin-1-yl}N-(pyridin-2-yl)-benzamide](/abs-image/US/2024/07/02/US12024520B2/abs.jpg.150x150.jpg)
Abstract:
The present disclosure relates, in general, to improved processes for the preparation of 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)-benzamide, particularly large-scale processes for manufacturing 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)benzamide and intermediates used in such processes.
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