Invention Grant
- Patent Title: Compound having affinity substance to soluble protein, cleavable portion and reactive group, or salt thereof
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Application No.: US16663791Application Date: 2019-10-25
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Publication No.: US12024549B2Publication Date: 2024-07-02
- Inventor: Kei Yamada , Yutaka Matsuda , Tomohiro Fujii , Natsuki Shikida , Reiko Yuji , Kazutaka Shimbo , Yuji Ito
- Applicant: Ajinomoto Co., Inc.
- Applicant Address: JP Tokyo
- Assignee: Ajinomoto Co., Inc.
- Current Assignee: Ajinomoto Co., Inc.
- Current Assignee Address: JP Tokyo
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP 17090679 2017.04.28
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C07K19/00
Abstract:
The present invention provides a technique enabling modification of a soluble protein and in particular regioselective modification of a soluble protein. More specifically, the present invention provides a compound having an affinity substance to a soluble protein, a cleavable portion, and a reactive group represented by the following Formula (I):
A-L-B-R (I)
wherein
A is an affinity substance to a soluble protein;
L is a cleavable linker which is a divalent group comprising a cleavable portion;
B is (a) a divalent group comprising a bioorthogonal functional group or (b) a divalent group comprising no bioorthogonal functional group; and
R is a reactive group to the soluble protein; or
a salt thereof.
A-L-B-R (I)
wherein
A is an affinity substance to a soluble protein;
L is a cleavable linker which is a divalent group comprising a cleavable portion;
B is (a) a divalent group comprising a bioorthogonal functional group or (b) a divalent group comprising no bioorthogonal functional group; and
R is a reactive group to the soluble protein; or
a salt thereof.
Information query
