Invention Grant
- Patent Title: HER2/neu-specific antibodies and methods of using same
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Application No.: US17308356Application Date: 2021-05-05
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Publication No.: US12024569B2Publication Date: 2024-07-02
- Inventor: Leslie S. Johnson , Ling Huang , Nadine Tuaillon , Ezio Bonvini
- Applicant: MacroGenics, Inc.
- Applicant Address: US MD Rockville
- Assignee: MacroGenics, Inc.
- Current Assignee: MacroGenics, Inc.
- Current Assignee Address: US MD Rockville
- Agency: MEDLER FERRO WOODHOUSE & MILLS PLLC
- The original application number of the division: US12933885
- Main IPC: C07K16/32
- IPC: C07K16/32 ; A61K39/395 ; A61K45/06 ; A61K39/00
Abstract:
This invention relates to antibodies that specifically bind HER2/neu, and particularly chimeric 4D5 antibodies to HER2/neu, which have reduced glycosylation as compared to known 4D5 antibodies. The invention also relates to methods of using the 4D5 antibodies and compositions comprising them in the diagnosis, prognosis and therapy of diseases such as cancer, autoimmune diseases, inflammatory disorders, and infectious disease.
Public/Granted literature
- US20220089773A1 HER2/neu-Specific Antibodies and Methods of Using Same Public/Granted day:2022-03-24
Information query
