Invention Grant
- Patent Title: Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy
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Application No.: US17810482Application Date: 2022-07-01
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Publication No.: US12024718B2Publication Date: 2024-07-02
- Inventor: Cecile Chartier-Courtaud , Krit Ritthipichai
- Applicant: Iovance Biotherapeutics, Inc.
- Applicant Address: US CA San Carlos
- Assignee: Iovance Biotherapeutics, Inc.
- Current Assignee: Iovance Biotherapeutics, Inc.
- Current Assignee Address: US CA San Carlos
- Agency: Morgan, Lewis & Bockius LLP
- Main IPC: C12N5/0783
- IPC: C12N5/0783 ; A01N1/02 ; A61K35/17 ; C12N9/22 ; C12N15/113
Abstract:
The present invention provides improved and/or shortened methods for expanding TILs and producing therapeutic populations of TILs, including novel methods for expanding TIL populations in a closed system that lead to improved efficacy, improved phenotype, and increased metabolic health of the TILs in a shorter time period, while allowing for reduced microbial contamination as well as decreased costs. The methods may comprise gene-editing at least a portion of the TILs to enhance their therapeutic efficacy. Such TILs find use in therapeutic treatment regimens.
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