This document describes a high efficiency dehumidification system (HEDS) and method of operating the same. The HEDS systems and physical implementations can include a variety of equipment, such as fans, fluid-conveying coils, tubing and pipes, heat transfer coils, vents, louvers, dampers, valves, fluid chillers, fluid heaters, and/or the like. Any of the implementations described herein can also include controls and logic, responsive to one or more sensors or other input devices, for controlling the equipment for each implementation described herein. The HEDS system utilizes heat transfer between the fluid within the fluid-conveying coils and air passing over the coils to convert humid air into dehumidified air.