A condensate drain system for a heating, ventilation, and/or air conditioning (HVAC) system includes a heat exchanger having a plurality of tubes configured to receive ambient air and fluidly coupled to a drain via a conduit, a valve positioned along the conduit between the plurality of tubes and the drain, where the valve is configured to enable a flow of condensate from within the plurality of tubes toward the drain in an open position and the block the flow in a closed position, and a controller configured to adjust a position of the valve based on feedback indicative of an operational state of the HVAC system.