Invention Grant
- Patent Title: Combined immunoassay and magnetic immunoassay methods for extended range of sensitivity
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Application No.: US17165282Application Date: 2021-02-02
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Publication No.: US12025614B2Publication Date: 2024-07-02
- Inventor: Jing Hua Hu , Antti Leo Oskari Virtanen , Cary James Miller
- Applicant: Abbott Point of Care Inc.
- Applicant Address: US NJ Princeton
- Assignee: Abbott Point of Care Inc.
- Current Assignee: Abbott Point of Care Inc.
- Current Assignee Address: US NJ Princeton
- Agency: Bozicevic, Field & Francis LLP
- Agent Edward J. Baba; Mandar A. Joshi
- The original application number of the division: US15836024 2017.12.08
- Main IPC: G01N33/543
- IPC: G01N33/543 ; G01N27/74 ; G01N33/539 ; G01N33/68

Abstract:
The present invention relates to methods that utilize a combination of immunoassay and magnetic immunoassay techniques to detect an analyte within an extended range of specified concentrations. In particular, a method includes forming, in a biological sample, a first complex of signal antibodies and analyte, and a second complex of the first complex and capture antibodies immobilized on magnetic beads, and contacting a first immunosensor with the biological sample to form a third complex localized on or near a surface of the first immunosensor. The first immunosensor includes an immobilized layer of capture antibodies configured to bind to the analyte, and the third complex includes the first complex bound to the immobilized layer of capture antibodies. The method further includes contacting a magnetic field localized around a second immunosensor with the biological sample such that the second complex is localized on or near a surface of the second immunosensor.
Public/Granted literature
- US20210156852A1 COMBINED IMMUNOASSAY AND MAGNETIC IMMUNOASSAY METHODS FOR EXTENDED RANGE OF SENSITIVITY Public/Granted day:2021-05-27
Information query
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