A method for performing configuration management of a memory device in predetermined communications architecture with aid of electronic fuse (eFuse) data preparation, associated apparatus and computer-readable medium are provided. The method may include: utilizing a memory controller to receive a first command from a host device through a transmission interface circuit of the memory controller; utilizing the memory controller to execute at least one procedure regarding MP initialization of the memory device, for example, operations of a first procedure among the at least one procedure may include obtaining eFuse information from an eFuse circuit, preparing protected eFuse data according to the eFuse information, and storing the protected eFuse data into a non-volatile (NV) memory; and utilizing the memory controller to send a first response to the host device through the transmission interface circuit, wherein the first response is sent to the host device in response to the first command.