A multi-disciplinary optimization (MDO) framework and workflow facilitates analysis and optimization of set of designs of a pressure-controlling component. The MDO workflow generally enables design workflow integration and automation, which can improve engineering efficiency, and enables automated optimization within the workflow automation, which facilitates performance and reliability improvement for product development. The MDO workflow enables the integration of computer-aided design (CAD), finite element analysis (FEA), digital manufacturing simulation (DMS), and optimization packages to facilitate testing and optimization of a set of pressure-controlling component designs. As such, the MDO framework and workflow improve the efficiency of the design process by providing a scalable solution for automating aspects of the design process for a set of designs of a pressure-controlling component, which may represent a product family or a set of competing alternative designs.