A minimally invasive surgical suture end locking device includes a hooking assembly, a clamping structure, a power rod and an external conduit. The hooking assembly includes an annular structure enclosed by a flexible material and a force application end, the clamping structure is configured to press the locking pin, the power rod is configured to press the clamping structure by linear motion, and the external conduit is provided with a through hole, the through hole being provided on the side of a position where the clamping structure and the power rod contact each other for a portion of the suture passing through the through area to be led out. There is provided in the present invention a device that allows to tighten and lock the suture directly at the end proximal to the position where the suture is led out from the human tissue.