Invention Grant
- Patent Title: Base editing of PCSK9 and methods of using same for treatment of disease
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Application No.: US17918057Application Date: 2021-04-09
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Publication No.: US12029795B2Publication Date: 2024-07-09
- Inventor: Alexandra Chadwick , Kallanthottathil G. Rajeev , Ellen Rohde , Christopher Cheng , Caroline Reiss
- Applicant: Verve Therapeutics, Inc.
- Applicant Address: US MA Boston
- Assignee: VERVE THERAPEUTICS, INC.
- Current Assignee: VERVE THERAPEUTICS, INC.
- Current Assignee Address: US MA Boston
- Agency: Wilson Sonsini Goodrich & Rosati
- International Application: PCT/US2021/026732 2021.04.09
- International Announcement: WO2021/207712A 2021.10.14
- Date entered country: 2022-10-10
- Main IPC: C07H21/04
- IPC: C07H21/04 ; A61K9/127 ; A61K31/7105 ; A61K38/46 ; A61K48/00 ; C07K14/515 ; C12N9/22 ; C12N15/11 ; C12N15/113 ; C12N15/90
Abstract:
Provided herein are compositions for gene modification or editing and methods of using same to treat or prevent certain conditions. Specific compositions and methods capable of safely and effectively editing gene targets expressed in the liver to durably lower LDL-C thereby treating a leading cause of cardiovascular disease are disclosed.
Public/Granted literature
- US20230159926A1 BASE EDITING OF PCSK9 AND METHODS OF USING SAME FOR TREATMENT OF DISEASE Public/Granted day:2023-05-25
Information query
