Methods and systems are provided for heat sanitizing a vehicle. In one example, a method may include, responsive to receiving a request for cleaning an interior of a vehicle, adjusting a position of a sun shade based on at least one of an ambient temperature outside of the vehicle and a sun load of the vehicle, and operating a heating, ventilation, and air-conditioning (HVAC) system to heat the interior above an upper threshold temperature for a first threshold duration. In this way, the HVAC system may be advantageously used to expose the vehicle interior to temperatures that kill or inactive microbes.