Invention Grant
- Patent Title: Substituted amide compounds useful as farnesoid X receptor modulators
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Application No.: US17431091Application Date: 2020-02-14
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Publication No.: US12030835B2Publication Date: 2024-07-09
- Inventor: Dean A. Wacker , Susheel Jethanand Nara , Srinivas Cheruku , Kandhasamy Sarkunam , Firoz Ali Jaipuri , Soodamani Thangavel , Rishikesh Narayan , Subba Reddy Bandreddy , Srinivas Jogi , Pavan Kalyan Kathi
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Gary Greenblatt
- International Application: PCT/US2020/018217 2020.02.14
- International Announcement: WO2020/168152A 2020.08.20
- Date entered country: 2021-08-13
- Main IPC: C07C233/61
- IPC: C07C233/61 ; C07D205/04 ; C07D207/06 ; C07D271/06 ; C07D277/64 ; C07D295/04 ; C07D309/04 ; C07D405/04 ; C07D405/14 ; C07D413/04

Abstract:
Disclosed are compounds of Formula (I) or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt or solvate thereof, wherein Q is a 5-membered heterocyclyl or 5-membered heteroaryl having 1 to 4 heteroatoms independently selected from N, O, and S, substituted with zero to 4 R1; and A, X1, X2, X3, X4, Z1, Z2, R1, R2, R3a, R3b, a, b, and d are defined herein. Also disclosed are methods of using these compounds to modulate the activity of farnesoid X receptor (FXR); pharmaceutical compositions comprising these compounds; and methods of treating a disease, disorder, or condition associated with FXR dysregulation, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.
Public/Granted literature
- US20220213026A1 SUBSTITUTED AMIDE COMPOUNDS USEFUL AS FARNESOID X RECEPTOR MODULATORS Public/Granted day:2022-07-07
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