A system and method for animal disease management is disclosed. The method includes receiving one or more images, one or more videos of one or more animals or a combination thereof and identifying one or more faces of the one or more animals in the one or more images, the one or more videos of one or more animals or a combination thereof. The method further includes extracting one or more facial features and one more muzzle features from the one or more faces and determining one or more facial changes and one or more muzzle changes. The method includes detecting presence or absence of one or more diseases in the one or more animals, predicting likelihood of the one or more diseases or a combination thereof based on the one or more facial changes, the one or more muzzle changes and the predefined information.