A pixel drive circuit, a resistance compensation method and a display panel are disclosed, wherein the compensation circuit in the pixel drive circuit is configured to compensate the resistance from the data line to the control end of the drive switch, so that the resistance of the data line to the control end of the drive switch in different pixel rows tend to be consistent, thus the efficiency of the same data line when charging the pixels in the pixel row at the far end is consistent with the efficiency at the near end.