Endoscopic imaging systems are disclosed herein. In some embodiments, an endoscopic imaging system can include an endoscope having a distal tip with a distal face configured to face a scene, such as a portion of a body cavity of a patient. The endoscope can further include first cameras for capturing first image data of the scene, a projector for projecting a light pattern into the scene, and second cameras for capturing second image data of the scene including the light pattern. A processor can be communicatively coupled to the first and second cameras for receiving the first and second image data. The processor can process the first and second image data to generate an image of the scene at the perspective of a virtual camera, and can vary the perspective, the aperture, the focus plane, and/or another parameter of the virtual camera without requiring the endoscope to be physically moved.