Disclosed are a method and an apparatus for uplink transmission and reception in a wireless communication system. A method of performing uplink transmission initiated by a terminal in a wireless communication system according to an embodiment of the present disclosure may include receiving, from a base station, configuration information including multiple uplink transmission resources related to a triggering event; and based on the triggering event for the uplink transmission, performing the uplink transmission to the base station in a transmission occasion, based on a first uplink transmission resource or a second uplink transmission resource of the multiple uplink transmission resources, wherein the first uplink transmission resource is related to a first control resource set (CORESET) group, and the second uplink transmission resource is related to a second CORESET group.