A coupling assembly according to certain embodiments is configured for use with an ostomy appliance, and generally includes a first coupling, a second coupling, and a clamp arrangement. The second coupling is mounted to the first coupling and surrounds at least a portion of the first coupling. The clamp arrangement is mounted to the second coupling and surrounds at least a portion of the second coupling. The clamp arrangement generally includes a clamp ring and a clamp lock. The clamp ring includes a first end portion, a second end portion, and a continuous body extending between the first end portion and the second end portion. The clamp lock is operable to selectively couple the first end portion with the second end portion to thereby discourage separation of the first coupling from the second coupling.