A bottle with an anti-scald handle is provided, including a bottle body internally provided with a cavity and a handheld portion independent of the bottle body, and the handheld portion is an interlayer structure internally provided with a cavity; an inward sunken space area is provided on the bottle body; a height of the handheld portion matches the space area, and when being placed in the space area, the handheld portion is fixed with the bottle body to form a handle of the bottle. On the premise of not changing the overall shape of the bottle, the handle portion is redesigned to make the handle have an anti-scald function and solve the problem of inconvenience to clean.