A device, optimization method and system for cooperative matching of heat dissipation and noise are disclosed. A hood is mounted on a base, and a power device, a fan and a radiator are mounted in the hood; an output shaft of the power device is fixedly connected to a rotary shaft of the fan through a bearing pedestal to drive the fan to rotate, and the bearing pedestal is fixed on the base; the radiator is fixed on a radiator support, and a lead screw assembly is disposed on the base, and is used for changing the relative distance between the radiator and the fan; and a fan cover is mounted on a side, facing the fan, of the radiator, and a plurality of anemographs are disposed on the other side of the radiator, and a plurality of microphones are symmetrically disposed on two sides of the fan.