A variable air volume (VAV) box includes a fan operable to induce airflow from a building space through the VAV box and discharge the airflow back to the building space, an air cleaning device positioned to clean the airflow through the VAV box before discharging the airflow back to the building space and configured to affect an air quality of the airflow, and a controller configured to operate the fan to modulate the airflow through the VAV box to achieve a target air quality for at least one of the airflow discharged from the VAV box or air within the building space.