Disclosed are a system and a method for digital radio interference mitigation. The system includes a first interface configured to receive a first digital signal associated with a satellite ground station; a second interface configured to receive a second digital signal associated with and acquired at a radio network transceiver; and a signal processing unit connected to the first and second interfaces and configured to mitigate a radio interference associated with the second digital signal in the first digital signal. This may improve a reception of satellite ground stations, especially upon coexistence with 5G cellular services in the C-band frequency spectrum.