Example apparatus disclosed herein to perform a cybersecurity investigation are to generate an information graph based on a set of information seeker tools in response to detection of a threat alert in a monitored network, and search the information graph for a reference pattern associated with a cybersecurity threat. Disclosed example apparatus are also to, in response to detection of a portion of the reference pattern in the information graph, (i) select a first one of information seeker tools associated with a first input-output relationship capable of expanding the portion of the reference pattern to complete the reference pattern, and (ii) execute the first one of information seeker tools to complete the reference pattern associated with the cybersecurity threat.