A driving method and a display device are disclosed. The driving method drives the display panel according to a common voltage look-up table, and the common voltage look-up table is generated by a method including: driving a preset area for display with a preset area gray-scale value; shooting the preset area and obtaining a brightness and a flicker value corresponding to the preset area; adjusting the common voltage value multiple times, and recording the common voltage value when the corresponding flicker value is the minimum as the optimal common voltage value; adjusting the preset area gray-scale value multiple times, and recording a plurality of optimal common voltage values corresponding to the adjusted preset area gray-scale values; and generating the common voltage look-up table according to the multiple preset area gray-scale values and the corresponding optimal common voltage values.