Embodiments described herein relate to systems, devices, and methods for use in the implementation of a brain-computer interface that tracks brain activity, with or without additional sensors providing additional sources of information, while presenting and updating a User Interface/User Experience that is strategically designed for high speed and accuracy of human-machine interaction. Embodiments described herein also relate to the implementation of a hardware agnostic brain-computer interface that uses neural signals to mediate user manipulation of machines and devices.