Invention Grant
- Patent Title: Compounds, compositions and methods for cancer patient stratification and cancer treatment
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Application No.: US17161612Application Date: 2021-01-28
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Publication No.: US12053476B2Publication Date: 2024-08-06
- Inventor: Timothy A. Lewis , Alex Burgin , Monica Schenone , Xiaoyun Wu , Heidi Greulich , Matthew Meyerson , Luc De Waal , Antje Margret Wengner , Knut Eis , Philip Lienau , Ulrike Sack , Martin Lange
- Applicant: BAYER PHARMA AKTIENGESELLSCHAFT , THE BROAD INSTITUTE, INC. , DANA-FARBER CANCER INSTITUTE, INC.
- Applicant Address: DE MA Berlin
- Assignee: Bayer Pharma Aktiengesellschaft,The Broad Institute, Inc.,Dana-Farber Cancer Institute, Inc.
- Current Assignee: Bayer Pharma Aktiengesellschaft,The Broad Institute, Inc.,Dana-Farber Cancer Institute, Inc.
- Current Assignee Address: DE Berlin; US MA Cambridge; US MA Boston
- Agency: Greenberg Traurig, LLP
- Agent Melissa Hunter-Ensor; Scott Goncher
- The original application number of the division: US16075077
- Main IPC: A61K31/5377
- IPC: A61K31/5377 ; A61K31/50 ; A61P35/00 ; C07D413/10
Abstract:
The present invention features improved compounds, especially
methods of identifying patients having cancer using biomarkers (e.g., PDE3A, SLFN12 and/or CREB3L1) that correlate with drug sensitivity and consequently treating a stratified patient population with an agent of the invention (e.g., Compounds 1-6 disclosed herein).
methods of identifying patients having cancer using biomarkers (e.g., PDE3A, SLFN12 and/or CREB3L1) that correlate with drug sensitivity and consequently treating a stratified patient population with an agent of the invention (e.g., Compounds 1-6 disclosed herein).
Public/Granted literature
- US20210236504A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR CANCER PATIENT STRATIFICATION AND CANCER TREATMENT Public/Granted day:2021-08-05
Information query
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