Invention Grant
- Patent Title: Bispecific OR-gate chimeric antigen receptor responsive to CD19 and CD20
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Application No.: US18238210Application Date: 2023-08-25
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Publication No.: US12053491B2Publication Date: 2024-08-06
- Inventor: Yvonne Y. Chen , Eugenia Zah , Michael C. Jensen
- Applicant: The Regents of the University of California , Seattle Children's Hospital
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California,Seattle Children's Hospital
- Current Assignee: The Regents of the University of California,Seattle Children's Hospital
- Current Assignee Address: US CA Oakland; US WA Seattle
- Agency: Foley Hoag LLP
- Agent David P. Halstead; Thi K. Dio
- Main IPC: A61K35/17
- IPC: A61K35/17 ; C07K14/705 ; C07K14/725 ; C07K16/28 ; C07K16/46 ; C12N5/0783 ; A61K38/00 ; A61K39/00
Abstract:
A CD19-OR-CD20 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD19-OR-CD20 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD19-OR-CD20 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR.
Public/Granted literature
- US11944648B2 Bispecific OR-gate chimeric antigen receptor responsive to CD19 and CD20 Public/Granted day:2024-04-02
Information query
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