- Patent Title: Glycan-masked engineered outer domains of HIV-1 gp120 and their use
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Application No.: US17587817Application Date: 2022-01-28
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Publication No.: US12053520B2Publication Date: 2024-08-06
- Inventor: Xuejun Chen , Jeffrey Boyington , Hongying Duan Holdsworth , Cheng Cheng , John R. Mascola
- Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Applicant Address: US MD Bethesda
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US MD Bethesda
- Agency: Klarquist Sparkman, LLP
- Main IPC: A61K39/21
- IPC: A61K39/21 ; C07K14/005 ; C07K14/16 ; C12N7/00 ; A61K39/00
Abstract:
Embodiments of immunogens based on the outer domain of HIV-1 gp120 and methods of their use and production are disclosed. Nucleic acid molecules encoding the immunogens are also provided. In several embodiments, the immunogens can be used to prime an immune response to gp120 in a subject, for example, to treat or prevent an HIV-1 infection in the subject.
Public/Granted literature
- US20220152194A1 GLYCAN-MASKED ENGINEERED OUTER DOMAINS OF HIV-1 GP120 AND THEIR USE Public/Granted day:2022-05-19
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