Invention Grant
- Patent Title: Pro-inflammatory and anti-cancer functions of toll-like receptor 4 antagonists
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Application No.: US17739953Application Date: 2022-05-09
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Publication No.: US12053522B2Publication Date: 2024-08-06
- Inventor: Jonathan C. Kagan
- Applicant: Children's Medical Center Corporation
- Applicant Address: US MA Boston
- Assignee: Children's Medical Center Corporation
- Current Assignee: Children's Medical Center Corporation
- Current Assignee Address: US MA Boston
- Agency: Fish & Richardson P.C.
- Main IPC: A61K39/39
- IPC: A61K39/39 ; A61K39/00
Abstract:
The present invention provides methods and compositions for specific activation of inflammatory responses in dendritic cells (DCs). 1-palmitoyl-2-arachidonyl-sn-glycero phosphorylcholine (PAPC) and its oxidized variant (oxPAPC) were identified to promote DC-mediated immunity, and are provided as adjuvants in immunostimulatory compositions, including vaccines.
Public/Granted literature
- US20230053338A1 PRO-INFLAMMATORY AND ANTI-CANCER FUNCTIONS OF TOLL-LIKE RECEPTOR 4 ANTAGONISTS Public/Granted day:2023-02-23
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