Invention Grant
- Patent Title: Process of preparing mRNA-loaded lipid nanoparticles
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Application No.: US17129666Application Date: 2020-12-21
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Publication No.: US12053551B2Publication Date: 2024-08-06
- Inventor: Shrirang Karve , Frank DeRosa , Ashish Sarode , Natalia Vargas Montoya , Priyal Patel
- Applicant: Translate Bio, Inc.
- Applicant Address: US MA Lexington
- Assignee: TRANSLATE BIO, INC.
- Current Assignee: TRANSLATE BIO, INC.
- Current Assignee Address: US MA Waltham
- Agency: LATHROP GPM LLP
- Agent James H. Velema, Esq.
- Main IPC: A61K9/51
- IPC: A61K9/51 ; A61K31/7105 ; B82Y5/00 ; B82Y40/00
Abstract:
The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of combining a solution of preformed lipid nanoparticles with lipid nanoparticles encapsulating mRNA, resulting in a composition of increased potency of mRNA encoded protein expression in vivo.
Public/Granted literature
- US20210186890A1 PROCESS OF PREPARING MRNA-LOADED LIPID NANOPARTICLES Public/Granted day:2021-06-24
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