The present invention relates to the field of audio processing technology, and more particularly, to a real-time audio processing method, system, device, and medium. The method including: receiving real-time audio data, and storing the audio data in a buffer, wherein the audio data is stored in a plurality of blocks in the buffer, and each block includes a certain number of sampling points; obtaining displacement data of a user's operation; said reading and playing one of the blocks at the corresponding position in the buffer, based on the speed and acceleration calculated from the displacement data. Achieving interaction between a user and real-time audio, including supporting a game player to perform interaction with real-time audio in a game to complete a scratching sound effect, restoring a mechanical scratching effect, and the transition of the sound effect is delicate and smooth, the hardware performance cost is small.