The present disclosure provides computer-implemented methods for difficulty-adjusted multi-participant interactivity. Also provided are computer readable media and computer devices that find use, e.g., in practicing the methods of the present disclosure. In certain aspects, the disclosure pertains to closed-loop assessment and adaptive methods and systems designed to equilibrate difficulty challenge levels across multiple (two or more) participants in interactive activities. In some embodiments, a first individual presents a first simulated challenge to a second individual and the second individual responds to it. Depending upon the response of the second individual to the first challenge, the second challenge presented by the first individual to the second individual may be unchanged, made more difficult, or made less difficult so that the modified second challenge is commensurate with the skills of the second individual. Thus, the disclosure provides customized experiences for individuals of disparate physical abilities to enjoyably interact with each other.