Invention Grant
- Patent Title: Sulfonylurea derivatives and uses thereof
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Application No.: US17618184Application Date: 2020-06-11
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Publication No.: US12054461B2Publication Date: 2024-08-06
- Inventor: Mark G. Bock , David Harrison , Jane E. Scanlon
- Applicant: NodThera Limited
- Applicant Address: GB Essex
- Assignee: NodThera Limited
- Current Assignee: NodThera Limited
- Current Assignee Address: GB Little Chesterford
- Agency: COOLEY LLP
- Agent Heidi A. Erlacher; Christine E. Dunne
- International Application: PCT/EP2020/066191 2020.06.11
- International Announcement: WO2020/249667A 2020.12.17
- Date entered country: 2021-12-10
- Main IPC: C07D231/40
- IPC: C07D231/40 ; C07D231/38

Abstract:
The present disclosure relates to compounds of Formula (I)
and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.
and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.
Public/Granted literature
- US20220227715A1 SULFONYLUREA DERIVATIVES AND USES THEREOF Public/Granted day:2022-07-21
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