Invention Grant
- Patent Title: Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
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Application No.: US18533894Application Date: 2023-12-08
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Publication No.: US12054465B2Publication Date: 2024-08-06
- Inventor: Hans Roland Lönn , Stephen Connolly , Steven Swallow , Staffan Po Karlsson , Carl-Johan Aurell , John Fritiof Pontén , Kevin James Doyle , Amanda Jane Van De Poël , Graham Peter Jones , David Wyn Watson , Jaqueline Anne Macritchie , Nicholas John Palmer
- Applicant: AstraZeneca AB
- Applicant Address: SE Södertälje
- Assignee: AstraZeneca AB
- Current Assignee: AstraZeneca AB
- Current Assignee Address: SE Södertälje
- Agency: Cooley LLP
- Main IPC: C07D267/10
- IPC: C07D267/10 ; A61K31/553 ; A61K45/06 ; A61P11/00 ; C07D409/10 ; C07D413/10 ; C07D413/12 ; C07D413/14 ; C07D417/12
![Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors](/abs-image/US/2024/08/06/US12054465B2/abs.jpg.150x150.jpg)
Abstract:
The present disclosure relates to certain (2S)—N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof),
that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.
that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.
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