Invention Grant
- Patent Title: KIF18A inhibitors
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Application No.: US17551105Application Date: 2021-12-14
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Publication No.: US12054476B2Publication Date: 2024-08-06
- Inventor: Nuria A. Tamayo , Abhisek Banerjee , James Alexander Brown , Michael J Frohn , Jian Jeffrey Chen , Kexue Li , Qingyian Liu , Jonathan Dante Low , Vu Ma , Liping H. Pettus , Mary Catherine Walton , Ana Elena Minatti , Matthew Paul Bourbeau , Lei Jia
- Applicant: AMGEN INC.
- Applicant Address: US CA Thousand Oaks
- Assignee: AMGEN INC.
- Current Assignee: AMGEN INC.
- Current Assignee Address: US CA Thousand Oaks
- Agency: MORRISON & FOERSTER LLP
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07D401/12 ; C07D405/14 ; C07D413/14 ; C07D419/14 ; C07D491/107

Abstract:
Compounds of formula (I):
as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.
as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.
Public/Granted literature
- US20220106293A1 KIF18A INHIBITORS Public/Granted day:2022-04-07
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