Invention Grant
- Patent Title: Compositions and methods for inhibiting phenyl triazole MLL1-WDR5 protein-protein interaction
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Application No.: US17944757Application Date: 2022-09-14
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Publication No.: US12054478B2Publication Date: 2024-08-06
- Inventor: Qidong You , Xiaoke Guo , Dongdong Li , Weilin Chen , Zhihui Wang
- Applicant: China Pharmaceutical University
- Applicant Address: CN Nanjing
- Assignee: HUYABIO International, LLC
- Current Assignee: HUYABIO International, LLC
- Current Assignee Address: US CA San Diego
- Agency: Eversheds Sutherland (US) LLP
- Priority: CN 181036588.0 2018.04.23
- The original application number of the division: US17078052 2020.10.22
- Main IPC: C07D405/12
- IPC: C07D405/12 ; C07D249/06 ; C07D401/12 ; C07D403/10
Abstract:
The present disclosure relates to the field of medicinal chemistry, in particular to a phenyl triazole MLL1-WDR5 protein-protein interaction inhibitor (I) and a preparation method thereof, and pharmacodynamics experiments prove that the compound of the present disclosure has relatively strong MLL1-WDR5 protein-protein interaction inhibition activity.
Public/Granted literature
- US20230098016A1 COMPOSITIONS AND METHODS FOR INHIBITING PHENYL TRIAZOLE MLL1-WDR5 PROTEIN-PROTEIN INTERACTION Public/Granted day:2023-03-30
Information query
